Novel RNA therapeutic targeting sodium channel genes for the treatment of  Genetic epilepsies front page preview

Novel RNA therapeutic targeting sodium channel genes for the treatment of Genetic epilepsies

Genetic epilepsies caused by mutations to voltage-gated sodium channels do not currently have adequate treatment options. These diseases begin in the early years of life, with infants suffering severe seizures as well as...

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Rapid Acting Pharmaceutical for Infectious Disease (RAPID) front page preview

Rapid Acting Pharmaceutical for Infectious Disease (RAPID)

Sepsis is a major challenge in the intensive care unit, where it is one of the leading causes of death. It arises unpredictability and can progress rapidly. Cilengitide, a potent inhibitor prevents bacterial binding to ...

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Highly Selective Inhibitors of HDAC6 for the Treatment of Cancers and Neurodegenerative Disease front page preview

Highly Selective Inhibitors of HDAC6 for the Treatment of Cancers and Neurodegenerative Disease

A novel structural class of highly-selective HDAC6 inhibitors. These patented small molecules have a unique non-hydroxamic acid chemical structure. The lead compound BAS-2 has been shown to inhibit glycolysis in triple ...

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Combating Inflammation and Fibrosis in Post-Surgery Glaucoma Patients front page preview

Combating Inflammation and Fibrosis in Post-Surgery Glaucoma Patients

Glaucoma is the leading cause of irreversible blindness and post-operative inflammation and fibrosis are determining factors in the failure of 30-50% of drainage surgeries. HyAGlauc is an implantable, biodegradable medic...

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Modifying Macrophages for the Treatment of Inflammatory Diseases front page preview

Modifying Macrophages for the Treatment of Inflammatory Diseases

Macrophages are a sub-type of immune cells that are critical for fighting infection in the body through the release of inflammatory and toxic mediators. However if inflammation persists these Macrophages become destructi...

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